Farmacja Polska (Dec 2023)
Analysis of content of selected heavy metals in dietary supplements available on the Polish market
Abstract
Background. Eating highly processed foods and lack of important nutrients in the diet may increase the need for dietary supplements. Their use allows consumers to supplement deficiencies of vitamins and other minerals necessary for the proper functioning of the body. However, in addition to valuable vitamins and minerals, often contain various types of plant components and they may be contaminated with heavy metals such as: cadmium (Cd), lead (Pb), mercury (Hg). Preparations with a high content of toxic elements may constitute an additional source of their uptake by the body and, apart from the desired nutritional effect, cause intoxication of the organism. Aim of the study. Comparative study on the level of cadmium, lead and mercury in herbal and vitamin-mineral preparations available on the Polish market. Material and methods. 93 samples, belonging to vitamin and vitamin-mineral preparations (50 contained plant components, while free from plant ingredients were in number of 43) were evaluated for selected heavy metals content using the flame atomic absorption spectrometry (FAAS) for cadmium and lead and using atomic absorption spectrometry with amalgamation technique for mercury. Results. Analysed samples of herbal and vitamin-mineral dietary supplements contained a low contamination of cadmium and lead and did not pose a risk to public health. The content of cadmium ranged from 0.010-0.710 mg/kg, while the lead ranged from 0.02 to 1.55 mg/kg. The average cadmium and lead contamination in preparations containing plant raw materials was significantly higher (p < 0.05) compared to the average content of this elements in preparations containing only synthetic ingredients. The level of cadmium and lead in all specimens did not exceed admissible value (1.0 mg/kg and 3.0 mg/kg respectively). The mercury concentration in the tested dietary supplements varied and ranged from 0.0005 to 0.1470 mg/kg. The average mercury content was almost 10 times higher in supplements containing plant raw materials, compared to the average content of this element in preparations containing only synthetic ingredients, but differences were not statistically significant (p < 0.088). Four preparations containing raw materials of plant origin exceeded the permissible mercury content (0.1 mg/kg). The tested dietary supplements were not a significant source of cadmium and mercury, but supply of lead from supplements was much bigger. Conclusion. Heavy metals were detected in all tested preparations. However, the supplements with plant raw materials contained significantly higher concentration of cadmium, lead and mercury compared to supplements that did not contain components of plant origin. Our research showed that the permissible amounts of mercury in the herbal supplements may be exceeded, moreover supplements with plant material may be a significant source of lead. Therefore further studies covering larger number of samples are needed to estimate the heavy metals contamination risk of dietary supplements. Keywords: heavy metals, atomic absorption spectrometry, contaminations, dietary supplements.
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