In vivo epidermal migration requires focal adhesion targeting of ACF7

Jiping Yue; Yao Zhang; Wenguang G. Liang; Xuewen Gou; Philbert Lee; Han Liu; Wanqing Lyu; Wei-Jen Tang; Shao-Yu Chen; Feng Yang; Hong Liang; Xiaoyang Wu

doi:10.1038/ncomms11692

Nature Communications (May 2016)

In vivo epidermal migration requires focal adhesion targeting of ACF7

Jiping Yue,
Yao Zhang,
Wenguang G. Liang,
Xuewen Gou,
Philbert Lee,
Han Liu,
Wanqing Lyu,
Wei-Jen Tang,
Shao-Yu Chen,
Feng Yang,
Hong Liang,
Xiaoyang Wu

Affiliations

Jiping Yue: Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Yao Zhang: State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China, Guanxi Normal University
Wenguang G. Liang: Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Xuewen Gou: Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Philbert Lee: Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Han Liu: Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Wanqing Lyu: Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Wei-Jen Tang: Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA
Shao-Yu Chen: Department of Pharmacology and Toxicology, University of Louisville Health Science Center
Feng Yang: State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China, Guanxi Normal University
Hong Liang: State Key Laboratory Cultivation Base for the Chemistry and Molecular Engineering of Medicinal Resources, Ministry of Science and Technology of China, Guanxi Normal University
Xiaoyang Wu: Ben May Department for Cancer Research, The University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, USA

DOI: https://doi.org/10.1038/ncomms11692
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 15

Abstract

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The spectraplakin protein ACF7 binds to actin at focal adhesions and targets microtubule plus ends to focal adhesions, promoting their disassembly. Here the authors reveal that ACF7 is phosphorylated by Src/FAK, and this regulates actin binding and focal adhesion dynamics in vitro and in vivo.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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