A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion

J. Maximilian Fels; Robert H. Bortz; Tanwee Alkutkar; Eva Mittler; Rohit K. Jangra; Jennifer S. Spence; Kartik Chandran

doi:10.1128/mBio.03616-20

mBio (Feb 2021)

A Glycoprotein Mutation That Emerged during the 2013–2016 Ebola Virus Epidemic Alters Proteolysis and Accelerates Membrane Fusion

J. Maximilian Fels,
Robert H. Bortz,
Tanwee Alkutkar,
Eva Mittler,
Rohit K. Jangra,
Jennifer S. Spence,
Kartik Chandran

Affiliations

J. Maximilian Fels: ORCiD; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Robert H. Bortz: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Tanwee Alkutkar: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Eva Mittler: ORCiD; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Rohit K. Jangra: ORCiD; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Jennifer S. Spence: Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA
Kartik Chandran: ORCiD; Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York, USA

DOI: https://doi.org/10.1128/mBio.03616-20
Journal volume & issue: Vol. 12, no. 1

Abstract

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The 2013–2016 outbreak of Ebola virus disease in West Africa demonstrated the potential for previously localized outbreaks to turn into regional, or even global, health emergencies. With over 28,000 cases and 11,000 confirmed deaths, this outbreak was over 50 times as large as any previously recorded.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal