Nature Communications (Dec 2017)

Identification and characterization of two functional variants in the human longevity gene FOXO3

  • Friederike Flachsbart,
  • Janina Dose,
  • Liljana Gentschew,
  • Claudia Geismann,
  • Amke Caliebe,
  • Carolin Knecht,
  • Marianne Nygaard,
  • Nandini Badarinarayan,
  • Abdou ElSharawy,
  • Sandra May,
  • Anne Luzius,
  • Guillermo G. Torres,
  • Marlene Jentzsch,
  • Michael Forster,
  • Robert Häsler,
  • Kathrin Pallauf,
  • Wolfgang Lieb,
  • Céline Derbois,
  • Pilar Galan,
  • Dmitriy Drichel,
  • Alexander Arlt,
  • Andreas Till,
  • Ben Krause-Kyora,
  • Gerald Rimbach,
  • Hélène Blanché,
  • Jean-François Deleuze,
  • Lene Christiansen,
  • Kaare Christensen,
  • Michael Nothnagel,
  • Philip Rosenstiel,
  • Stefan Schreiber,
  • Andre Franke,
  • Susanne Sebens,
  • Almut Nebel

DOI
https://doi.org/10.1038/s41467-017-02183-y
Journal volume & issue
Vol. 8, no. 1
pp. 1 – 12

Abstract

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FOXO3 is one of the few established longevity genes. Here, the authors fine-map the FOXO3-longevity association to two intronic SNPs and, using luciferase assays and EMSAs, show that these SNPs affect binding of transcription factors CTCF and SRF and associate with FOXO3 expression.