Vaspin is a compensatory molecule in the pathogenesis of metabolic obesity-induced disorders

Abstract

Background. The development of disabling effects in obesity is connected to the functioning disorders of adipose tissue hormones — the adipokines, including vaspin. The nature of changes in vaspin content in Ukrainians with different body weight requires further investigation. The purpose was to investigate vaspin content in circulating blood in Kharkіv citizens, depending on the body mass index, degree and topography of adipose tissue deposit, blood insulin levels, the index of insulin resistance HOMA and adipose tissue level. Materials and methods. Content of vaspin in circulation in 250 people aged 65.48 ± 11.86 years has been defined by imunnoenzyme method. The nature of the relationship between vaspin and the body mass index, waist and thigh circumference, fat content, blood insulin levels and insulin resistance index HOMA were evaluated. Results. The blood vaspin level was found to depends on the relative content of adipose tissue. Decreased sensitivity of tissues to insulin (NOMA-index more than 4.00) among representatives of the Ukrainian population is accompanied by increased blood vaspin more than 650 ng/ml. Conclusions. The perspective direction is to detect reasons of gender differences in vaspin level in obesity.

Keywords

• obesity
• overweight
• vaspin