DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation

Xiaohua Xu; Chou-Wei Chang; Min Li; Kenneth Omabe; Nhung Le; Yi-Hsuan Chen; Feng Liang; Yilun Liu

doi:10.1038/s41467-023-36968-1

Nature Communications (Mar 2023)

DNA replication initiation factor RECQ4 possesses a role in antagonizing DNA replication initiation

Xiaohua Xu,
Chou-Wei Chang,
Min Li,
Kenneth Omabe,
Nhung Le,
Yi-Hsuan Chen,
Feng Liang,
Yilun Liu

Affiliations

Xiaohua Xu: Thermo Fisher Scientific
Chou-Wei Chang: Vesigen Therapeutics
Min Li: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope
Kenneth Omabe: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope
Nhung Le: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope
Yi-Hsuan Chen: Department of Computer Science, University of Southern California
Feng Liang: Neuroscience Graduate Program, University of Southern California
Yilun Liu: Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope

DOI: https://doi.org/10.1038/s41467-023-36968-1
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 16

Abstract

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RECQ4 mutations contribute to multiple developmental diseases and tumorigenesis. Here the authors describe how a highly oncogenic RECQ4 mutation alters the control of DNA synthesis, leading to abnormal DNA content and cell growth.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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