Chinese Journal of Lung Cancer (Aug 2009)
The Pitfall of Transbronchial Lung Biopsy in the Small Cell Carcinoma--Attach 64 Cases Immunohistochemistry Research
Abstract
Background and objective It is very difficult to make diagnosis on the HE section to small cell lung carcinoma by bronchoscopic and easy to make misdiagnosis, we can avoid this by using immunohistochemical staining to diagnose differentially among the small cell carcinoma, poorly differentiated squamous cell carcinoma, atypical form carcinoid and lymphoma. Methods 64 cases of lung biopsy by bronchoscopic were consistency with small cell carcinoma and stained by immunochemistry for Ki67, CD56, TTF-1, CgA, Syn, P63, CK5/6, LCA, 34βE12. Results For the 64 cases, we diagnosed 61 cases to the small cell carcinoma, 1 case to the poorly differentiated squamous cell carcinoma and 2 cases to the atypical carcinoid after IHC stain. Conclusion It is the different therapy among the small cell carcinoma, poorly differentiated squamous cell carcinoma, atypical form carcinoid and lymphoma, so we can identify the diagnosis and differential diagnosis with IHC thoroughly, accordingly decrease incidence of misdiagnosis.
