Screening of Rosemary Essential Oils with Different Phytochemicals for Antioxidant Capacity, Keratinocyte Cytotoxicity, and Anti-Proliferative Activity

Yeqin Huang; Heran Xu; Mengting Ding; Jingyi Li; Di Wang; Hui Li; Meiyu Sun; Fei Xia; Hongtong Bai; Min Wang; Meiling Mo; Lei Shi

doi:10.3390/molecules28020586

Molecules (Jan 2023)

Screening of Rosemary Essential Oils with Different Phytochemicals for Antioxidant Capacity, Keratinocyte Cytotoxicity, and Anti-Proliferative Activity

Yeqin Huang,
Heran Xu,
Mengting Ding,
Jingyi Li,
Di Wang,
Hui Li,
Meiyu Sun,
Fei Xia,
Hongtong Bai,
Min Wang,
Meiling Mo,
Lei Shi

Affiliations

Yeqin Huang: Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
Heran Xu: Beijing Key Laboratory of Plant Research and Development, College of Chemistry and Materials Engineering of Beijing Technology and Business University, Beijing 100048, China
Mengting Ding: Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
Jingyi Li: Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
Di Wang: Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
Hui Li: Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
Meiyu Sun: Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
Fei Xia: Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
Hongtong Bai: Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China
Min Wang: Beijing Key Laboratory of Plant Research and Development, College of Chemistry and Materials Engineering of Beijing Technology and Business University, Beijing 100048, China
Meiling Mo: Sinno Cosmetics Co., Ltd., Zhongshan 528451, China
Lei Shi: Key Laboratory of Plant Resources and Beijing Botanical Garden, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China

DOI: https://doi.org/10.3390/molecules28020586
Journal volume & issue: Vol. 28, no. 2
p. 586

Abstract

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Nowadays, the demand for rosemary essential oils (REOs) in the cosmetic, food, and pharmaceutical industries is increasing, and the abundant germplasm resources of rosemary provide more possibilities for functional applications. The REOs from six cultivars were selected to evaluate and compare their bioactivities. REOs have good cellular antioxidant activity in scavenging reactive oxygen species, and the technology for order preference by similarity to an ideal solution (TOPSIS)-random forest multivariate model indicated that ‘Dutch Mill’ REO has the best antioxidant activity, which is closely related to its verbenone content. In addition, α-pinene-dominant REOs are more toxic to human keratinocytes, which is closely related to the content of α-pinene, as revealed by multivariate analyses. Moreover, anti-proliferative assays on six cancer cell lines showed that all REOs have a higher anti-proliferative ability against human pancreatic cancer cell line SW1990 and gastric epithelial cell line NCI-N87. Among them, ‘Miss Jessopp’s Upright’ and ‘Blue Lagoon’ REOs exhibit more prominent anti-proliferative activity. Our study provides a reference value for exploring the application potential of different REOs by evaluating their differences in chemical composition and bioactivity.

Published in Molecules

ISSN: 1420-3049 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Science: Chemistry: Organic chemistry
Website: http://www.mdpi.com/journal/molecules

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