Frontiers in Bioscience-Landmark (Jun 2022)
Expression of Novel Kinase MAP3K19 in Various Cancers and Survival Correlations
- Khoa Nguyen,
- Hassan Yousefi,
- Thomas Cheng,
- Justin Magrath,
- Alifiani B. Hartono,
- Madlin Alzoubi,
- Katherine Hebert,
- Courtney K. Brock,
- Maryl K. Wright,
- Charles Ethan Byrne,
- Andrew Rivera,
- Sam C. Okpechi,
- Margarite Delores Matossian,
- Henri Wathieu,
- Steven Elliott,
- Mark J. Mondrinos,
- Sean B. Lee,
- Bridgette M. Collins-Burow,
- Suresh K. Alahari,
- David H. Drewry,
- Matthew E. Burow
Affiliations
- Khoa Nguyen
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Hassan Yousefi
- Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, LA 70112, USA
- Thomas Cheng
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Justin Magrath
- Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Alifiani B. Hartono
- Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Madlin Alzoubi
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Katherine Hebert
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Courtney K. Brock
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Maryl K. Wright
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Charles Ethan Byrne
- Department of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA
- Andrew Rivera
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Sam C. Okpechi
- Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, LA 70112, USA
- Margarite Delores Matossian
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Henri Wathieu
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Steven Elliott
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Mark J. Mondrinos
- Department of Biomedical Engineering, Tulane University, New Orleans, LA 70112, USA
- Sean B. Lee
- Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Bridgette M. Collins-Burow
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- Suresh K. Alahari
- Department of Biochemistry and Molecular Biology, LSUHSC School of Medicine, New Orleans, LA 70112, USA
- David H. Drewry
- UNC Eshelman School of Pharmacy and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
- Matthew E. Burow
- Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA
- DOI
- https://doi.org/10.31083/j.fbl2706196
- Journal volume & issue
-
Vol. 27,
no. 6
p. 196
Abstract
Mitogen Activated Protein (MAP) kinases are a category of serine/threonine kinases that have been demonstrated to regulate intracellular events including stress responses, developmental processes, and cancer progression Although many MAP kinases have been extensively studied in various disease processes, MAP3K19 is an understudied kinase whose activities have been linked to lung disease and fibroblast development. In this manuscript, we use bioinformatics databases starBase, GEPIA, and KMPlotter, to establish baseline expressions of MAP3K19 in different tissue types and its correlation with patient survival in different cancers.
Keywords
