Study on Carbamazepine induced electrocardiographic, blood pressure and echocardiographic changes in the dog

Abstract

Carbamazepine is used as an anticonvulsant drug in the treatment of simple slight convulsion and generalized tonic-clonic, trigeminal neuralgia, and also as preventive agent in manic depressive. Carbamazepine reduces synaptic transmission by prolonging the inactivity of cellular sodium-potassium pump. Considering the clinical use of carbamazepine, the current study aimed to evaluate its cardiac effects in dogs. In this experimental-interventional study, fourteen native 1.5-2 years old female mixed breed dogs were procured and after laboratory testing and physical examination to ensure their general health status, they were divided into treatment and control groups (7 dogs in each group). On day zero, before drug administration, the electrocardiogram, echocardiogram and blood pressure was recorded. Both groups were maintained in the same conditions and carbamazepine was given orally to the treatment group for 7 days (with a dose of 8 mg/kg). After completing the administration period, the electrocardiogram, echocardiogram and blood pressure was obtained once again and the data were analyzed by one-way ANOVA. Blood pressure was significantly reduced in the treatment group (pp<0.05). According to the results of the current study, it was found that carbamazepine could decrease blood pressure and induce notable alterations in the electrocardiogram and echocardiogram of dogs.

Keywords

• carbamazepin
• electrocardiogram
• echocardiogram
• blood pressure
• dog