Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish

Zhibin Liu; Haiqing Tu; Yunsi Kang; Yuanyuan Xue; Dongyuan Ma; Chengtian Zhao; Huiyan Li; Lu Wang; Feng Liu

doi:10.1038/s41467-019-09403-7

Nature Communications (Apr 2019)

Primary cilia regulate hematopoietic stem and progenitor cell specification through Notch signaling in zebrafish

Zhibin Liu,
Haiqing Tu,
Yunsi Kang,
Yuanyuan Xue,
Dongyuan Ma,
Chengtian Zhao,
Huiyan Li,
Lu Wang,
Feng Liu

Affiliations

Zhibin Liu: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Haiqing Tu: State Key Laboratory of Proteomics, National Center of Biomedical Analysis
Yunsi Kang: Institute of Evolution and Marine Biodiversity, Ocean University of China
Yuanyuan Xue: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Dongyuan Ma: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Chengtian Zhao: Institute of Evolution and Marine Biodiversity, Ocean University of China
Huiyan Li: State Key Laboratory of Proteomics, National Center of Biomedical Analysis
Lu Wang: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences
Feng Liu: State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences

DOI: https://doi.org/10.1038/s41467-019-09403-7
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 11

Abstract

Read online

Haematopoietic stem and progenitor cells (HSPCs) produce all blood lineages and arise from the haemogenic endothelium (HE) during embryogenesis. Here the authors show that genes specific to cilia formation are required for HSPC development in the HE in zebrafish through transduction of Notch signal.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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