TECRL deficiency results in aberrant mitochondrial function in cardiomyocytes

Cuilan Hou; Xunwei Jiang; Han Zhang; Junmin Zheng; Qingzhu Qiu; Yongwei Zhang; Xiaomin Sun; Meng Xu; Alex Chia Yu Chang; Lijian Xie; Tingting Xiao

doi:10.1038/s42003-022-03414-9

Communications Biology (May 2022)

TECRL deficiency results in aberrant mitochondrial function in cardiomyocytes

Cuilan Hou,
Xunwei Jiang,
Han Zhang,
Junmin Zheng,
Qingzhu Qiu,
Yongwei Zhang,
Xiaomin Sun,
Meng Xu,
Alex Chia Yu Chang,
Lijian Xie,
Tingting Xiao

Affiliations

Cuilan Hou: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University
Xunwei Jiang: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University
Han Zhang: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University
Junmin Zheng: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University
Qingzhu Qiu: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University
Yongwei Zhang: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University
Xiaomin Sun: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University
Meng Xu: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University
Alex Chia Yu Chang: Department of Cardiology and Shanghai Institute Precision Medicine, Ninth People’s Hospital, School of medicine, Shanghai Jiao Tong University
Lijian Xie: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University
Tingting Xiao: Department of Cardiology, Shanghai Children’s Hospital, School of medicine, Shanghai Jiao Tong University

DOI: https://doi.org/10.1038/s42003-022-03414-9
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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The endoplasmic reticulum protein TECRL promotes mitochondrial function in cardiomyocytes and its knockout in mice leads to cardiac dysfunction, decreased mitochondria function, and elevated levels of reactive oxygen species.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

About the journal