The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease

Hirokazu Miki; Shingen Nakamura; Masahiro Oura; Masafumi Nakamura; Ryohei Sumitani; Kimiko Sogabe; Mamiko Takahashi; Tomoko Maruhashi; Takeshi Harada; Shiro Fujii; Hirofumi Hamano; Masateru Kondo; Naoto Okada; Itsuro Endo; Masahiro Abe

doi:10.1002/jha2.402

eJHaem (May 2022)

The importance of retaining physical functions to prevent skeletal‐related events in multiple myeloma patients with bone disease

Hirokazu Miki,
Shingen Nakamura,
Masahiro Oura,
Masafumi Nakamura,
Ryohei Sumitani,
Kimiko Sogabe,
Mamiko Takahashi,
Tomoko Maruhashi,
Takeshi Harada,
Shiro Fujii,
Hirofumi Hamano,
Masateru Kondo,
Naoto Okada,
Itsuro Endo,
Masahiro Abe

Affiliations

Hirokazu Miki: Division of Transfusion Medicine and Cell Therapy Tokushima University Hospital Tokushima Japan
Shingen Nakamura: Department of Community Medicine and Medical Science Tokushima University Graduate School of Biomedical Sciences Tokushima Japan
Masahiro Oura: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Masafumi Nakamura: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Ryohei Sumitani: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Kimiko Sogabe: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Mamiko Takahashi: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Tomoko Maruhashi: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Takeshi Harada: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Shiro Fujii: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Hirofumi Hamano: Clinical Research Center for Developmental Therapeutics Tokushima University Hospital Tokushima Japan
Masateru Kondo: Department of Pharmacy Tokushima University Hospital Tokushima Japan
Naoto Okada: Department of Pharmacy Tokushima University Hospital Tokushima Japan
Itsuro Endo: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan
Masahiro Abe: Department of Hematology Endocrinology and Metabolism, Institute of Biomedical Sciences Tokushima University Graduate School Tokushima Japan

DOI: https://doi.org/10.1002/jha2.402
Journal volume & issue: Vol. 3, no. 2
pp. 480 – 483

Abstract

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Abstract This study was undertaken to identify baseline conditions and triggering factors for skeletal‐related events (SRE) in multiple myeloma (MM) patients treated with denosumab. During the median follow‐up of 17 months, SRE occurred in 6 out of 52 newly diagnosed patients and in 5 out of 23 relapsed/refractory patients. Bone fractures occurred by falling down due to orthostatic hypotension and/or muscle weakness in three out of four cases with amyloid light‐chain (AL) amyloidosis. A loss of balance and falling down appear to be triggering factors for SRE, especially in frail MM patients with AL amyloidosis, indicating the importance of retaining physical functions to prevent SRE.

Published in eJHaem

ISSN: 2688-6146 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://onlinelibrary.wiley.com/journal/26886146

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Abstract

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