Estimation the level of Neudesin in Polycystic ovarian syndrome patients

Abstract

Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic ovulation dysfunction and overabundance of androgens; it affects women at reproductive age. The aim of the current study were to detect the analytic estimation of serum Gremlin as well as studying the relation between this biomarker and Body Mass Index (BMI), age, waist /hip ratio and type of infertility in Polycystic ovarian syndrome patients. Methods: The current study was conducted on 90 women (60 patients with polycystic ovary syndrome and 30 healthy control) ranging in their ages from 15-39 years in period from March to June, 2023. Blood samples were collected from women and serum samples prepare to estimate the serum levels of Gremlin. Results: The results indicated that there was a significant increase (P-Value< 0.05) in Gremlin levels in patients group when compare with control group. Also, after dividing the group of patients into three groups according to ages, we notice a significant increase (P-Value< 0.05) in Gremlin levels in age less than 20 years when compare with age 20-29 years and age 30-39 years, and a significant increase (P-Value< 0.05) in Gremlin levels in age 20-29 years when compare with age 30-39 years. On the other hand, when dividing the group of patients according to body mass index we notice a significant decrease (P-Value< 0.05) in Gremlin level in overweight group when compare with obese group and significant decrease (P-Value< 0.05) in Gremlin level in moderate W/H ratio group when compare with high W/H ratio group and no significant difference found between primary and secondary infertility. Conclusion: The current study concluded that a Gremlin is a prognostic marker in early detection of polycystic ovarian syndrome.