Molecules (May 2023)

Synthetic Routes to Approved Drugs Containing a Spirocycle

  • Nazar Moshnenko,
  • Alexander Kazantsev,
  • Evgeny Chupakhin,
  • Olga Bakulina,
  • Dmitry Dar’in

DOI
https://doi.org/10.3390/molecules28104209
Journal volume & issue
Vol. 28, no. 10
p. 4209

Abstract

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The use of spirocycles in drug discovery and medicinal chemistry has been booming in the last two decades. This has clearly translated into the landscape of approved drugs. Among two dozen clinically used medicines containing a spirocycle, 50% have been approved in the 21st century. The present review focuses on the notable synthetic routes to such drugs invented in industry and academia, and is intended to serve as a useful reference source of synthetic as well as general drug information for researchers engaging in the design of new spirocyclic scaffolds for medicinal use or embarking upon analog syntheses inspired by the existing approved drugs.

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