PLoS ONE (Jan 2012)

Probable congenital transmission of reticuloendotheliosis virus caused by vaccination with contaminated vaccines.

  • Kai Wei,
  • Zhenhong Sun,
  • Shufen Zhu,
  • Wenlong Guo,
  • Pengcheng Sheng,
  • Zunmin Wang,
  • Changliang Zhao,
  • Qingyou Zhao,
  • Ruiliang Zhu

DOI
https://doi.org/10.1371/journal.pone.0043422
Journal volume & issue
Vol. 7, no. 8
p. e43422

Abstract

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Contaminated vaccine is one unexpected and potential origin of virus infection. In order to investigate the most likely cause of disease in a broiler breeder company of Shandong Province, all 17 batches of live-virus vaccines used in the affected flocks and 478 tissue samples were tested by dot-blot hybridization, nested PCR, and IFA. The results suggested the outbreak of disease was most probably due to the vaccination of REV-contaminated MD-CVI988/Rispens vaccines and ND-LaSota+IB-H120 vaccines. Furthermore, the REV was probably transmitted to the commercial chickens through congenital transmission.