Does the presence of praziquantel-related adverse events affect the health community's perception toward the mass chemopreventive program in the highest prevalence area of Schistosomiasis in Indonesia? Study in Dodolo village, Napu Valley, Central Sulawesi

Abstract

Objective: This study was to determine the relationship between a praziquantel-related adverse event with the health community perception to chemopreventive of Schistosomiasis in Dodolo village, Napu Valley, Central Sulawesi. Methods: A cross-sectional study was conducted among the 79 residents of Dodolo village, who following praziquantel-mass drug administration. A-questionnaire was used to collect demographic information of the subject who participated in the study, the presence of treatment-related symptoms, and community perception. The health perception was based on the health belief model (HBM) framework. Data were analyzed using Chi-square. Result: The incidence of praziquantel-related adverse events was 92% (73), with the highest frequency were nausea (69%), vomit (57%), and headache (47%). The total number of treatments related to symptoms was significantly correlated with age (p 0.030). 78% (62) of participants had a supportive perceived susceptibility, 71% (56) participants had a supportive perceived severity, 63% (50) participants had supportive perceived benefits, meanwhile 58% (46) had a not supportive perceived barrier to praziquantel mass drug administration. The presence of praziquantel-related adverse events was significantly correlated with a perceived barrier of the participant to the chemopreventive program. Conclusion: The Dodolo community had a supportive health perception for the success of the Schistosomiasis elimination program, despite the high frequency of adverse events after praziquantel consumption.

Keywords

• Adverse-event praziquantel
• Community perception
• Schistosomiasis
• Dodolo village