Antibiotics (Sep 2021)

Use of Dalbavancin in Skin, Bone and Joint Infections: A Real-Life Experience in an Italian Center

  • Lucia Brescini,
  • Filippo Della Martera,
  • Gianluca Morroni,
  • Sara Mazzanti,
  • Maria Di Pietrantonio,
  • Paolo Mantini,
  • Bianca Candelaresi,
  • Francesco Pallotta,
  • Silvia Olivieri,
  • Valentina Iencinella,
  • Sefora Castelletti,
  • Emanuele Cocci,
  • Rosaria G. Polo,
  • Salvatore Veccia,
  • Oscar Cirioni,
  • Marcello Tavio,
  • Andrea Giacometti

DOI
https://doi.org/10.3390/antibiotics10091129
Journal volume & issue
Vol. 10, no. 9
p. 1129

Abstract

Read online

Dalbavancin is a lipoglycopeptide approved for the treatment of acute bacterial skin and skin structure infections (ABSSSI). The aim of the study was to evaluate the efficacy and safety in all patients who received at least one administration of dalbavancin. Methods: We carried out a retrospective study of the use of dalbavancin in 55 patients at the Azienda Ospedaliera Ospedali Riuniti Umberto I (Ancona, Italy) from February 2017 to May 2020 and compared “on label” and “off label” use of dalbavancin in ABSSSI and non-ABSSSI. Results: A total of 55 patients were included in the study. The median age was 61 years; 51% had ABSSSI; 24% had prosthetic joint infections, and 14% had osteomyelitis. A total of 53% received a single 1500 mg infusion of dalbavancin, and 18% received a second dose 14 days later; 24% of patients received further doses at 14-day intervals. In 91% of cases, patients achieved clinical objectives with dalbavancin: 96% of patients with ABSSSI and 69% of those with prosthetic joint infections. Conclusions: Dalbavancin was shown to have an excellent tolerability profile and to be a highly successful therapeutic approach even in those cases treated “off-label”.

Keywords