Ameliorative effect of Psidium guajava (l.) leaf aqueous extract on aluminium nitrate-induced liver damage in female Wistar rats

Abstract

Abstract Background Aluminium nitrate and other aluminium-containing compounds have been demonstrated to cause several health challenges. Psidium guajava L) is a well known cultivated tree with hepatoprotective nature and radical scavenging ability. Methods Twenty-five (25) female Wistar rats with average weight of 195 g were grouped into five groups (n = 5), with their weights measured and recorded weekly throughout the period of 21 days of the research. Control (group A), 32.5 mg/kg AL only (group B), 30 mg/kg AL + 250 mg/kg PGLE (group C), 20 mg/kg AL + 500 mg/kg PGLE (group D) and 10 mg/kg AL + 750 mg/kg PGLE (group E). Histological examination of the liver was done using Hematoxylin and Eosin stain. Results Various degenerative changes were observed in the liver architecture following aluminum nitrate administration when compared with the control group. Significant regenerative changes similar to control were observed following administration of high dose of Psidium guajava. Conclusion The results obtained in this study revealed that aqueous extract of Psidium guajava leaves possess good hepato-protective properties.

Keywords

• Psidium guajava
• Wistar rats
• Hepatocytes
• Aluminum