A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

Donghai Xiong; Yian Wang; Ming You

doi:10.1038/s41467-020-18546-x

Nature Communications (Oct 2020)

A gene expression signature of TREM2hi macrophages and γδ T cells predicts immunotherapy response

Donghai Xiong,
Yian Wang,
Ming You

Affiliations

Donghai Xiong: Center for Disease Prevention Research and Department of Pharmacology and Toxicology, Medical College of Wisconsin
Yian Wang: Center for Disease Prevention Research and Department of Pharmacology and Toxicology, Medical College of Wisconsin
Ming You: Center for Disease Prevention Research and Department of Pharmacology and Toxicology, Medical College of Wisconsin

DOI: https://doi.org/10.1038/s41467-020-18546-x
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 12

Abstract

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Most cancer patients do not respond to immune checkpoint therapies and the availability of predictive biomarkers is limited. Here the authors propose a signature enriched for genes of TREM2hi macrophages and γδ T cells to predict response to immunotherapy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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