Research progress on liposomes and periodontal disease

Abstract

Liposomes are microspheres that are similar to cell membranes. They have good sustained release, biocompatibility and targeting ability and can reduce the toxicity of encapsulated drugs. This article reviews the research progress of the use of liposomes in periodontal drug delivery systems and periodontal tissue engineering scaffolds. Liposomes have shown unique advantages and broad prospects in the field of periodontal drug delivery. Liposomes loaded with bioactive molecules and combined with periodontal tissue engineering scaffolds can improve the pharmacokinetics and local efficacy of these molecules. Modification of various extracellular matrix proteins on the surface of the scaffolds can promote the absorption of liposomes. Attachment of these proteins to the surface of the scaffold can reduce the requirement for bioactive molecules, improve the effective conversion rate and prolong the half-life of the scaffold in vivo. However, the development, clinical efficacy and safety evaluation of new liposomes still need to be further explored.

Keywords

• periodontal disease，
• periodontal tissue engineering，
• liposome，
• controlled release microspheres，
• drug delivery system ，
• bioactive molecule，
• scaffold for tissue engineering，