Study of Anticonvulsive Effects of Equeous Extract of Origanumvulgare on Chemical Kindling in Male Mice

Abstract

Introduction: Epilepsy is one of the most common neurological disorders that affect on many aspects of people's lives. Multiple treatment methods were used for epileptic patients. Recently, treatment effects of medicinal plants on epilepsy have been investigated. In attention to components of Origanum vulgare and the usage of it in traditional medicine as an anti-convulsion herb, this study was carried out to assess the anti-convulsive effects of Origanumvulgare extract on chemical kindling model of epilepsy. Methods: The present experimental study has been carried out on 40 male mice that they have been chosen randomly and divided into 5 equal experimental groups, including one control group received only Pentylenetetrazole (PTZ), one sham group received distilled water and three experimental groups that 30 minutes before PTZ injection received equeous extract of Origanumvulgare in doses of 400, 600 and 800 mg/kg of body weight via gavage tube. Chemical kindling was performed on all of them for 12 times intraperitoneal injection of 45 mg/kg of body weight of PTZ at every 48 hours. Data analyses were carried out by one way ANOVA and Tukey post-hoc test. Results: Data analysis showed that administration of Origanum vulgare extract has a significant effect on chemical kindling. It decreased the progress of seizure stages significantly (P˂0.05) and increased latency time for onset of seizure considerably (P˂0.05), but it had no significant effect on seizure duration.  Conclusion: The results obtained from the present study showed aqueous extract of Origanum vulgare plant had anti convulsant effect on chemical kindling. Thus, it may be useful for epilepsy treatment.

Keywords

• Seizures
• kindling
• Pentylenetetrazole
• Pharmaceutical Plants