Biomarkers of alcohol abuse potentially predict delirium, delirium duration and mortality in critically ill patients

Nikolaus Schreiber; Alexander C. Reisinger; Stefan Hatzl; Nikolaus Schneider; Laura Scholz; Markus Herrmann; Michael Kolland; Max Schuller; Alexander H. Kirsch; Kathrin Eller; Christiane Kink; Simon Fandler-Höfler; Alexander R. Rosenkranz; Gerald Hackl; Philipp Eller

iScience (Oct 2023)

Biomarkers of alcohol abuse potentially predict delirium, delirium duration and mortality in critically ill patients

Nikolaus Schreiber,
Alexander C. Reisinger,
Stefan Hatzl,
Nikolaus Schneider,
Laura Scholz,
Markus Herrmann,
Michael Kolland,
Max Schuller,
Alexander H. Kirsch,
Kathrin Eller,
Christiane Kink,
Simon Fandler-Höfler,
Alexander R. Rosenkranz,
Gerald Hackl,
Philipp Eller

Affiliations

Nikolaus Schreiber: Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria; Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria
Alexander C. Reisinger: Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria
Stefan Hatzl: Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria
Nikolaus Schneider: Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria
Laura Scholz: Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria
Markus Herrmann: Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
Michael Kolland: Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria
Max Schuller: Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria
Alexander H. Kirsch: Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria
Kathrin Eller: Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria
Christiane Kink: Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria
Simon Fandler-Höfler: Department of Neurology, Medical University Graz, Graz, Austria
Alexander R. Rosenkranz: Department of Internal Medicine, Division of Nephrology, Medical University of Graz, Graz, Austria
Gerald Hackl: Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria
Philipp Eller: Department of Internal Medicine, Intensive Care Unit, Medical University of Graz, Graz, Austria; Corresponding author

Journal volume & issue: Vol. 26, no. 10
p. 108044

Abstract

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Summary: Carbohydrate-deficient transferrin (CDT) and the γ-glutamyltransferase-CDT derived Anttila-Index are established biomarkers for sustained heavy alcohol consumption and their potential role to predict delirium and mortality in critically ill patients is not clear. In our prospective observational study, we included 343 consecutive patients admitted to our ICU, assessed the occurrence of delirium and investigated its association with biomarkers of alcohol abuse measured on the day of ICU admission. 35% of patients developed delirium during ICU stay. We found significantly higher CDT levels (p = 0.011) and Anttila-Index (p = 0.001) in patients with delirium. CDT above 1.7% (OR 2.06), CDT per percent increase (OR 1.26, AUROC 0.75), and Anttila-Index per unit increase (OR 1.28, AUROC 0.74) were associated with delirium development in adjusted regression models. Anttila-Index and CDT also correlated with delirium duration exceeding 5 days. Additionally, Anttila-Index above 4, Anttila-Index per unit increase, and CDT per percent increase were independently associated with hospital mortality.

Published in iScience

ISSN: 2589-0042 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Science
Website: http://www.cell.com/iscience/home

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