EVALUATION OF COMMON INTERACTIONS INCLUDING ANTI-INFECTIVE DRUGS IN PATIENTS UNDERWENT AUTOLOGOUS AND ALLOGENEIC STEM CELL TRANSPLANTATION

Abstract

Objective: Hematopoietic stem cell transplantation is a challenging process involving polypharmacy. Drug-drug interactions are common due to the large number of drugs used in patients, and antiinfectives are frequently involved in interactions due to their widespread use. Methodology: In our study, the drugs used by a total of 100 patients with 50 autologous and 50 allogeneic bone marrow transplants for 10 days before transplantation, on the day of transplantation and for 10 days after transplantation were examined retrospectively in terms of interaction. Two paid softwares and two free softwares were used to examine interactions. The obtained data were analyzed with Microsoft Excel program. Results: 1017 different interactions were detected in patients with allogeneic bone marrow transplantation and 725 different interactions in patients with autologous bone marrow transplantation. It was observed that 342 interactions were common in the two transplant types. Interactions involving anti-infectives have been studied and the data showed antifungals, antibacterials and antivirals cause significant interaction load. Some interactions were found to be dependent on the transplant process. Conclusion: Allogeneic bone marrow transplantation and autologous bone marrow transplantation are challenging processes in which intensive drug therapy is applied. Knowing the interactions that are common to both types of transplantation and the interactions involving anti-infectives specific to a certain period of the transplantation process allows the process to be managed effectively. It is important to manage interactions in physician-clinical pharmacist collaboration