Nature Communications (Apr 2018)

Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid

  • Melissa Birol,
  • Sunil Kumar,
  • Elizabeth Rhoades,
  • Andrew D. Miranker

DOI
https://doi.org/10.1038/s41467-018-03651-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 12

Abstract

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Toxic gain-of-function by islet amyloid polypeptide (IAPP) is thought to be mediated by membrane poration. Here the authors develop diluted-FRET to show that changes in pore structure correlate with onset of toxicity inside insulin secreting cells.