Nature Communications (Apr 2018)
Conformational switching within dynamic oligomers underpins toxic gain-of-function by diabetes-associated amyloid
Abstract
Toxic gain-of-function by islet amyloid polypeptide (IAPP) is thought to be mediated by membrane poration. Here the authors develop diluted-FRET to show that changes in pore structure correlate with onset of toxicity inside insulin secreting cells.