Nature Communications (Apr 2022)
Phagosomal signalling of the C-type lectin receptor Dectin-1 is terminated by intramembrane proteolysis
- Torben Mentrup,
- Anna Yamina Stumpff-Niggemann,
- Nadja Leinung,
- Christine Schlosser,
- Katja Schubert,
- Rebekka Wehner,
- Antje Tunger,
- Valentin Schatz,
- Patrick Neubert,
- Ann-Christine Gradtke,
- Janina Wolf,
- Stefan Rose-John,
- Paul Saftig,
- Alexander Dalpke,
- Jonathan Jantsch,
- Marc Schmitz,
- Regina Fluhrer,
- Ilse D. Jacobsen,
- Bernd Schröder
Affiliations
- Torben Mentrup
- Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
- Anna Yamina Stumpff-Niggemann
- Biochemical Institute, Christian-Albrechts-University of Kiel
- Nadja Leinung
- Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
- Christine Schlosser
- Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Medical Faculty, University of Augsburg
- Katja Schubert
- Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute
- Rebekka Wehner
- Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
- Antje Tunger
- Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
- Valentin Schatz
- Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg and University of Regensburg
- Patrick Neubert
- Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg and University of Regensburg
- Ann-Christine Gradtke
- Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
- Janina Wolf
- Biochemical Institute, Christian-Albrechts-University of Kiel
- Stefan Rose-John
- Biochemical Institute, Christian-Albrechts-University of Kiel
- Paul Saftig
- Biochemical Institute, Christian-Albrechts-University of Kiel
- Alexander Dalpke
- Institute of Medical Microbiology and Virology, University Hospital Carl Gustav Carus, Medical Faculty, Technische Universität Dresden
- Jonathan Jantsch
- Institute of Clinical Microbiology and Hygiene, University Hospital of Regensburg and University of Regensburg
- Marc Schmitz
- Institute of Immunology, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
- Regina Fluhrer
- Biochemistry and Molecular Biology, Institute of Theoretical Medicine, Medical Faculty, University of Augsburg
- Ilse D. Jacobsen
- Research Group Microbial Immunology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knöll Institute
- Bernd Schröder
- Institute of Physiological Chemistry, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden
- DOI
- https://doi.org/10.1038/s41467-022-29474-3
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 18
Abstract
Dectin-1 is a critical component of the innate sensing repertoire which is involved in pattern based recognition of fungal pathogens. Here the authors show that intramembrane proteolysis is involved in the regulation of the antifungal host response by termination of the phagosomal signalling of Dectin-1.
