Albumin dialysis with MARS for the treatment of anabolic steroid-induced cholestasis

Francia C. Díaz; Esteban Sáez-González; Salvador Benlloch; Diego Álvarez-Sotomayor; Isabel Conde; Begoña Polo; María García; María Rodríguez; Martín Prieto

Annals of Hepatology (Nov 2016)

Albumin dialysis with MARS for the treatment of anabolic steroid-induced cholestasis

Francia C. Díaz,
Esteban Sáez-González,
Salvador Benlloch,
Diego Álvarez-Sotomayor,
Isabel Conde,
Begoña Polo,
María García,
María Rodríguez,
Martín Prieto

Affiliations

Francia C. Díaz: Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain; Correspondence and reprint request:
Esteban Sáez-González: Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain
Salvador Benlloch: Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain; Experimental Hepatology Unit, La Fe Medical Research Institute. Valencia, Spain; CIBERehd (Networked Biomedical Research Center in Hepatic and Digestive Diseases). Spain
Diego Álvarez-Sotomayor: Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain
Isabel Conde: Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain; Experimental Hepatology Unit, La Fe Medical Research Institute. Valencia, Spain
Begoña Polo: Department of Paediatric Gastroenterology. La Fe University Hospital, Valencia. Spain
María García: Department of Gastroenterology, Hepatology and Liver Transplantation Unit. La Fe University Hospital, Valencia. Spain; Experimental Hepatology Unit, La Fe Medical Research Institute. Valencia, Spain
María Rodríguez: Department of Digestive Diseases. Liver Unit. Hospital General Universitario Alicante. Spain
Martín Prieto: Experimental Hepatology Unit, La Fe Medical Research Institute. Valencia, Spain; Experimental Hepatology Unit, La Fe Medical Research Institute. Valencia, Spain; CIBERehd (Networked Biomedical Research Center in Hepatic and Digestive Diseases). Spain

Journal volume & issue: Vol. 15, no. 6
pp. 939 – 943

Abstract

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Background and aims. Steroid-related hepatotoxicity has become one of the most relevant causes of drug induced liver cholestasis. Some patients do not improve after standard medical treatment (SMT) and may therefore require other approaches, like extracorporeal liver support.Material and methods. We report four cases of patients with pruritus, abnormal liver function tests and biopsy-proven anabolic steroid-induced cholestasis who were unresponsive to SMT. They underwent treatment with albumin dialysis (Molecular Adsorbent Recirculating System -MARS®-). A minimum of two MARS sessions were performed.Results. After MARS® procedure, patients’ symptoms improved, as well as liver function tests, thus avoiding liver transplantation.Conclusion. Albumin dialysis appears as a valuable therapeutic option for the management of anabolic steroid-induced cholestasis in patients that are unresponsive to SMT.

Published in Annals of Hepatology

ISSN: 1665-2681 (Print); 2659-5982 (Online)
Publisher: Elsevier
Country of publisher: Spain
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine
Website: https://www.journals.elsevier.com/annals-of-hepatology

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