3-Chlorokenpaullone

Abstract

3-Chlorokenpaullone (9-bromo-3-chloro-7,12-dihydroindolo[3,2-d][1]benz­azepin-6(5H)-one) is a novel derivative of the protein kinase inhibitor kenpaullone. The title compound was synthesized by a Fischer indole reaction from 8-chloro-3,4-dihydro-1H-1-benzazepin-2,5-dione and 4-bromophenylhydrazine. It was characterized for structural identity by elemental analysis and spectroscopic methods (IR, NMR, EI-MS) and checked for purity by HPLC.

Keywords

• kenpaullone
• paullone
• protein kinase inhibitor
• Fischer indole synthesis