A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Giulia E. Tyzack; Claire E. Hall; Christopher R. Sibley; Tomasz Cymes; Serhiy Forostyak; Giulia Carlino; Ione F. Meyer; Giampietro Schiavo; Su-Chun Zhang; George M. Gibbons; Jia Newcombe; Rickie Patani; András Lakatos

doi:10.1038/s41467-017-01283-z

Nature Communications (Oct 2017)

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

Giulia E. Tyzack,
Claire E. Hall,
Christopher R. Sibley,
Tomasz Cymes,
Serhiy Forostyak,
Giulia Carlino,
Ione F. Meyer,
Giampietro Schiavo,
Su-Chun Zhang,
George M. Gibbons,
Jia Newcombe,
Rickie Patani,
András Lakatos

Affiliations

Giulia E. Tyzack: John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, E.D. Adrian Building
Claire E. Hall: Department of Molecular Neuroscience, UCL Institute of Neurology, University College London
Christopher R. Sibley: Division of Brain Sciences, Imperial College London, Burlington Danes Building Du Cane Road
Tomasz Cymes: John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, E.D. Adrian Building
Serhiy Forostyak: Institute of Experimental Medicine ASCR and Charles University in Prague, Department of Neuroscience
Giulia Carlino: Department of Molecular Neuroscience, UCL Institute of Neurology, University College London
Ione F. Meyer: Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, University College London
Giampietro Schiavo: Sobell Department of Motor Neuroscience & Movement Disorders, UCL Institute of Neurology, University College London
Su-Chun Zhang: Waisman Center, University of Wisconsin
George M. Gibbons: John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, E.D. Adrian Building
Jia Newcombe: Department of Neuroinflammation, UCL Institute of Neurology, University College London
Rickie Patani: Department of Molecular Neuroscience, UCL Institute of Neurology, University College London
András Lakatos: John van Geest Centre for Brain Repair, Department of Clinical Neurosciences, University of Cambridge, E.D. Adrian Building

DOI: https://doi.org/10.1038/s41467-017-01283-z
Journal volume & issue: Vol. 8, no. 1
pp. 1 – 17

Abstract

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Astrocytes can have protective or detrimental effects on neurons during injury, but the molecular mechanisms that determine these different states are unresolved. Here the authors identify a pathway via neuronal EphB1 that induces neuroprotective signalling in astrocytes through ephrin-B1 mediated STAT3 activation, which is impaired in models of amyotrophic lateral sclerosis.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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