Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication

Lily E. Adams; Kenneth H. Dinnon; Yixuan J. Hou; Timothy P. Sheahan; Mark T. Heise; Ralph S. Baric

doi:10.1128/mBio.03149-20

mBio (Apr 2021)

Critical ACE2 Determinants of SARS-CoV-2 and Group 2B Coronavirus Infection and Replication

Lily E. Adams,
Kenneth H. Dinnon,
Yixuan J. Hou,
Timothy P. Sheahan,
Mark T. Heise,
Ralph S. Baric

Affiliations

Lily E. Adams: ORCiD; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Kenneth H. Dinnon: Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Yixuan J. Hou: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Timothy P. Sheahan: Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Mark T. Heise: ORCiD; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Ralph S. Baric: ORCiD; Department of Microbiology & Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

DOI: https://doi.org/10.1128/mBio.03149-20
Journal volume & issue: Vol. 12, no. 2

Abstract

Read online

SARS-CoV-2 (the causative agent of COVID-19) is a major public health threat and one of two related coronaviruses that have caused epidemics in modern history. A method of screening potential infectible hosts for preemergent and future emergent coronaviruses would aid in mounting rapid response and intervention strategies during future emergence events.

Published in mBio

ISSN: 2161-2129 (Print); 2150-7511 (Online)
Publisher: American Society for Microbiology
Country of publisher: United States
LCC subjects: Science: Microbiology
Website: https://journals.asm.org/journal/mbio

About the journal