ANALISIS SGPT-SGOT EKSTRAK ETANOL DAGING BUAH PARE (Momordica charantia L.) PADA TIKUS JANTAN PUTIH GALUR WISTAR

Abstract

The traditional medicine in Indonesia which is the cultural heritage and has become an integral part of the life of the nation Indonesia, want to be employed in the formal health care system. As the circulation of drugs in general terms, traditional medicine should fulfill the requirements of quality, safe, and efficacious. This study aims to analyze the levels of SGPT, SGOT of suspension of the ethanol extract of bitter melon fruit (Momordica charantia L.) by orally. The study was conducted using a white male Wistar rats amounted to 36 animals, divided into 6 groups. Each group consisted of 6 male white rats. Group I (control) were given 0.5% CMC solution of 2.5 ml/200 g BW. Group II was given a suspension dosage doses of bitter melon fruit extract ethanol 0.5 g/kg, then consecutive group III with the test preparation doses of 1 g/kg, the test preparation group IV were given a dose of 2 g/kg, group V was given dosage test dose of 4 g/kg, and group VI were given the highest dose of the test preparation 8 g/kg. The results of acute toxicity tests on white male Wistar rats showed that administration of ethanol extract of peroral dosage suspension pare (Momordica charantia L.) single dose on white male Wistar rats from the dose of 0.5 g/kg until a dose of 8 g/kg did not significantly influence the value of SGPT, SGOT.

Keywords

• bitter melon fruit
• toxicity
• blood chemistry