Journal of Blood Medicine (Aug 2024)

Clinical and Biomarker Characteristic of Lymphoma Patients in Hasan Sadikin Lymphoma Registry

  • Oehadian A,
  • Kartikasari A,
  • Mersiana L,
  • Gunadi SV,
  • Fungani G,
  • Vidyaniati P,
  • Prasetya D,
  • Wijaya I,
  • Fianza PI,
  • Fadjari TH,
  • Sutedjo NN

Journal volume & issue
Vol. Volume 15
pp. 341 – 349

Abstract

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Amaylia Oehadian,1 Andini Kartikasari,2 Lusi Mersiana,1 Stephanie Victoria Gunadi,3 Gusti Fungani,1 Putri Vidyaniati,1 Dimmy Prasetya,1 Indra Wijaya,1 Pandji Irani Fianza,1 Trinugroho Heri Fadjari,1 Nanny Natalia Sutedjo4 1Division of Hematology and Oncology Medic, Internal Medicine Department, Faculty of Medicine, Padjadjaran University/ Dr. Hasan Sadikin General Hospital, Bandung, Indonesia; 2Bandung City Regional General Hospital, Bandung, Indonesia; 3Internal Medicine Department, Faculty of Medicine, Padjadjaran University/ Dr. Hasan Sadikin General Hospital, Bandung, Indonesia; 4Endocrinology and Metabolism Division, Internal Medicine Department, Faculty of Medicine, Padjadjaran University/ Dr. Hasan Sadikin General Hospital, Bandung, IndonesiaCorrespondence: Amaylia Oehadian, Department of Internal Medicine, Padjadjaran University/ Dr. Hasan Sadikin General Hospital, Jl. Pasteur No. 38, Pasteur, Bandung, West Java, 40161, Indonesia, Email [email protected]: No specific data have been systematically collected regarding lymphoma patient characteristics, while non-Hodgkin lymphoma (NHL) is identified as the 7th most common cancer and Hodgkin lymphoma (HL) is the 28th. Inflammation plays an important role in the pathogenesis and progression of lymphoma. Malnutrition is an adverse prognostic factor in lymphoma. Systemic Inflammatory Index (SII), Prognostic Nutritional Index (PNI), and Advanced Lung Cancer Inflammation Index (ALI) were biomarkers depicting inflammation and nutritional status. This study aims to describe the clinical and biomarker characteristics of both HL and NHL patients.Methods: This descriptive study used a cross-sectional design, and data were collected from Hasan Sadikin Hospital lymphoma registry from January 2020 to November 2023. Demographic, staging, and histopathological data were extracted. Three biomarkers were evaluated. Survival curves were drawn using Kaplan–Meier curve analysis, and the log rank test was used for comparison of survival between early and advanced stage.Results: A total of 271 patients were recruited as participants, and the majority (80.5%) had NHL, with diffuse large B-cell lymphoma (DLBCL) being the most common histopathological type (50.5%). Early disease was observed in two-thirds of patients, and low-risk International Prognostic Index (IPI) score was the most common prognostic score found (95%). SII was slightly higher in early compared to advanced stages. Treatment response was evaluated from 101 patients, and complete response was observed in 44.5%. Two-year overall survival (OS) was 93.1%, with median survival 22.7 (95% CI 21.9– 23.5) months. In early stage, the median survival was slightly longer than in advanced stage [23.0 (95% CI 22.2– 23.8) vs 21.6 (95% CI 19.3– 23.8) months, P= 0.09].Conclusion: Hodgkin lymphoma and DLBCL had similar clinical and biomarker characteristics. There were slight differences between the three biomarkers SII, ALI, and PNI based on the disease stage. Almost all patients still survived at 2-year follow-up.Keywords: lymphoma, non-Hodgkin lymphoma, Hodgkin lymphoma, registry

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