Cell free DNA; diagnostic and prognostic approaches to oncology

Abstract

Cell-free DNA (cfDNA) are un-encapsulated DNA fragments present in biological fluids ranging in an average size of up to 200 base pairs. The novel use of cfDNA is a prime candidate in the diagnostic and prognostic approach to unveiling many inflammatory diseases, especially cancer. Moreover, their potential as biomarkers is due to their ubiquitous presence in the body, non-invasive nature, and aiding in a different autopsy method. This review will focus on the diagnostic and prognostic potential of cfDNA as non-invasive biomarkers in oncology.

Keywords

• Cell-free DNA (cfDNA)
• Cancer
• Tumor
• Diagnostic potential
• Prognostic potential
• Apoptosis