An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics

Susana I. Ramos; Zarmeen M. Mussa; Elisa N. Falk; Balagopal Pai; Bruno Giotti; Kimaada Allette; Peiwen Cai; Fumiko Dekio; Robert Sebra; Kristin G. Beaumont; Alexander M. Tsankov; Nadejda M. Tsankova

doi:10.1038/s41467-022-34975-2

Nature Communications (Dec 2022)

An atlas of late prenatal human neurodevelopment resolved by single-nucleus transcriptomics

Susana I. Ramos,
Zarmeen M. Mussa,
Elisa N. Falk,
Balagopal Pai,
Bruno Giotti,
Kimaada Allette,
Peiwen Cai,
Fumiko Dekio,
Robert Sebra,
Kristin G. Beaumont,
Alexander M. Tsankov,
Nadejda M. Tsankova

Affiliations

Susana I. Ramos: Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai
Zarmeen M. Mussa: Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai
Elisa N. Falk: Department of Neuroscience, Icahn School of Medicine at Mount Sinai
Balagopal Pai: Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai
Bruno Giotti: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Kimaada Allette: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Peiwen Cai: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Fumiko Dekio: Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai
Robert Sebra: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Kristin G. Beaumont: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Alexander M. Tsankov: Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai
Nadejda M. Tsankova: Department of Pathology, Molecular, and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-022-34975-2
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 18

Abstract

Read online

Late prenatal development of the human neocortex encompasses a critical period of gliogenesis and cortical expansion. Here, authors use human transcriptomics to capture transience and diversity of cells in middle and late prenatal development, including glial progenitor signatures.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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