Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Min Li; Shuya Li; Han Zhou; Xinfeng Tang; Yi Wu; Wei Jiang; Zhigang Tian; Xuechang Zhou; Xianzhu Yang; Yucai Wang

doi:10.1038/s41467-020-14963-0

Nature Communications (Feb 2020)

Chemotaxis-driven delivery of nano-pathogenoids for complete eradication of tumors post-phototherapy

Min Li,
Shuya Li,
Han Zhou,
Xinfeng Tang,
Yi Wu,
Wei Jiang,
Zhigang Tian,
Xuechang Zhou,
Xianzhu Yang,
Yucai Wang

Affiliations

Min Li: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Shuya Li: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Han Zhou: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Xinfeng Tang: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Yi Wu: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Wei Jiang: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Zhigang Tian: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China
Xuechang Zhou: College of Chemistry and Environmental Engineering, Shenzhen University
Xianzhu Yang: Institutes for Life Sciences, School of Medicine and National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology
Yucai Wang: Division of Molecular Medicine, Hefei National Laboratory for Physical Sciences at Microscale, The CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China

DOI: https://doi.org/10.1038/s41467-020-14963-0
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 16

Abstract

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The presence of several biological barriers impede the efficacy of nano-mediated drug delivery for solid cancer therapy. Here, the authors develop a nano-pathogenoid system that targets circulating neutrophils and show that it overcomes these biological barriers and improves tumour targeting and efficacy.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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