Communications Biology (Feb 2023)
Omics analysis of Mycobacterium tuberculosis isolates uncovers Rv3094c, an ethionamide metabolism-associated gene
- Li Wan,
- Peilei Hu,
- Lili Zhang,
- Zhao-Xi Wang,
- Joy Fleming,
- Bo Ni,
- Jianjun Luo,
- Cha-Xiang Guan,
- Liqiong Bai,
- Yunhong Tan,
- Haican Liu,
- Na Li,
- Tongyang Xiao,
- Hua Bai,
- Yong-An Zhang,
- Xian-En Zhang,
- Kanglin Wan,
- Lijun Bi,
- Songying Ouyang,
- Hongtai Zhang
Affiliations
- Li Wan
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
- Peilei Hu
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
- Lili Zhang
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
- Zhao-Xi Wang
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, Fujian Key Laboratory of Special Marine Bio-resources Sustainable Utilization, College of Life Sciences, Fujian Normal University
- Joy Fleming
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
- Bo Ni
- Hunan Chest Hospital
- Jianjun Luo
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
- Cha-Xiang Guan
- Department of Physiology, Xiangya School of Medicine, Central South University
- Liqiong Bai
- Hunan Chest Hospital
- Yunhong Tan
- Hunan Chest Hospital
- Haican Liu
- State Key Laboratory for Infectious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Na Li
- State Key Laboratory for Infectious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Tongyang Xiao
- State Key Laboratory for Infectious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Hua Bai
- Hunan Chest Hospital
- Yong-An Zhang
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, Fujian Key Laboratory of Special Marine Bio-resources Sustainable Utilization, College of Life Sciences, Fujian Normal University
- Xian-En Zhang
- National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences
- Kanglin Wan
- State Key Laboratory for Infectious Diseases Prevention and Control, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention
- Lijun Bi
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
- Songying Ouyang
- Provincial University Key Laboratory of Cellular Stress Response and Metabolic Regulation, the Key Laboratory of Innate Immune Biology of Fujian Province, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of the Ministry of Education, Fujian Key Laboratory of Special Marine Bio-resources Sustainable Utilization, College of Life Sciences, Fujian Normal University
- Hongtai Zhang
- Key Laboratory of RNA Biology, Institute of Biophysics, Chinese Academy of Sciences
- DOI
- https://doi.org/10.1038/s42003-023-04433-w
- Journal volume & issue
-
Vol. 6,
no. 1
pp. 1 – 14
Abstract
A multi-omic analysis of 11 Mycobacterium tuberculosis (Mtb) isolates with different drug resistance profiles leads to the discovery of Rv3094c, an enzyme capable of activating the clinically relevant Mtb drug, ethionamide.
