Nature Communications (Aug 2021)

Place fields of single spikes in hippocampus involve Kcnq3 channel-dependent entrainment of complex spike bursts

  • Xiaojie Gao,
  • Franziska Bender,
  • Heun Soh,
  • Changwan Chen,
  • Mahsa Altafi,
  • Sebastian Schütze,
  • Matthias Heidenreich,
  • Maria Gorbati,
  • Mihaela-Anca Corbu,
  • Marta Carus-Cadavieco,
  • Tatiana Korotkova,
  • Anastasios V. Tzingounis,
  • Thomas J. Jentsch,
  • Alexey Ponomarenko

DOI
https://doi.org/10.1038/s41467-021-24805-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 13

Abstract

Read online

Hippocampal pyramidal cells encode an animal’s location by single action potentials and complex spike bursts. The authors show that Kcnq3-containing M-channels synergistically with GABAergic inputs coordinate complex spike bursts during theta oscillations, which is a key mechanism for spatial coding by single spikes.