Communications Biology (Aug 2022)
Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth
- Rossella Delle Donne,
- Rosa Iannucci,
- Laura Rinaldi,
- Luca Roberto,
- Maria A. Oliva,
- Emanuela Senatore,
- Domenica Borzacchiello,
- Luca Lignitto,
- Giorgio Giurato,
- Francesca Rizzo,
- Assunta Sellitto,
- Francesco Chiuso,
- Salvatore Castaldo,
- Giovanni Scala,
- Virginia Campani,
- Valeria Nele,
- Giuseppe De Rosa,
- Chiara D’Ambrosio,
- Corrado Garbi,
- Andrea Scaloni,
- Alessandro Weisz,
- Concetta Ambrosino,
- Antonella Arcella,
- Antonio Feliciello
Affiliations
- Rossella Delle Donne
- Department of Molecular Medicine and Medical Biotechnology, University Federico II
- Rosa Iannucci
- Department of Molecular Medicine and Medical Biotechnology, University Federico II
- Laura Rinaldi
- Department of Molecular Medicine and Medical Biotechnology, University Federico II
- Luca Roberto
- Biogem, Ariano Irpino
- Maria A. Oliva
- I.R.C.C.S Neuromed
- Emanuela Senatore
- Department of Molecular Medicine and Medical Biotechnology, University Federico II
- Domenica Borzacchiello
- Department of Molecular Medicine and Medical Biotechnology, University Federico II
- Luca Lignitto
- Department of Molecular Medicine and Medical Biotechnology, University Federico II
- Giorgio Giurato
- Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry SMS, University of Salerno
- Francesca Rizzo
- Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry SMS, University of Salerno
- Assunta Sellitto
- Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry SMS, University of Salerno
- Francesco Chiuso
- Department of Molecular Medicine and Medical Biotechnology, University Federico II
- Salvatore Castaldo
- I.R.C.C.S Neuromed
- Giovanni Scala
- Department of Biology, University Federico II
- Virginia Campani
- Department of Pharmacy, University Federico II
- Valeria Nele
- Department of Pharmacy, University Federico II
- Giuseppe De Rosa
- Department of Pharmacy, University Federico II
- Chiara D’Ambrosio
- Proteomics, Metabolomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council
- Corrado Garbi
- Department of Molecular Medicine and Medical Biotechnology, University Federico II
- Andrea Scaloni
- Proteomics, Metabolomics and Mass Spectrometry Laboratory, ISPAAM, National Research Council
- Alessandro Weisz
- Laboratory of Molecular Medicine and Genomics, Department of Medicine, Surgery and Dentistry SMS, University of Salerno
- Concetta Ambrosino
- Biogem, Ariano Irpino
- Antonella Arcella
- I.R.C.C.S Neuromed
- Antonio Feliciello
- Department of Molecular Medicine and Medical Biotechnology, University Federico II
- DOI
- https://doi.org/10.1038/s42003-022-03639-8
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
The E3 ubiquitin ligase praja2 is expressed in glioblastoma (GBM), targets the kinase suppressor of Ras 2 for degradation and attenuates oxidative metabolism. Nanoparticle-mediated delivery of praja2 siRNA to GBM-bearing mice reduces tumour size.
