Nature Communications (Jun 2021)

Aryl radical-mediated N-heterocyclic carbene catalysis

  • Yuki Matsuki,
  • Nagisa Ohnishi,
  • Yuki Kakeno,
  • Shunsuke Takemoto,
  • Takuya Ishii,
  • Kazunori Nagao,
  • Hirohisa Ohmiya

DOI
https://doi.org/10.1038/s41467-021-24144-2
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 8

Abstract

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Use of aryl halides as coupling precursors typically occurs through transition metal catalysis and/or photoredox chemistry, which requires some combination of light, metals, and oxidants or reductants. Here, the authors show a method to generate aryl radicals from halides using only an NHC organocatalyst.