Nature Communications (Jul 2018)

Integrated genetic and epigenetic analysis of myxofibrosarcoma

  • Koichi Ogura,
  • Fumie Hosoda,
  • Yasuhito Arai,
  • Hiromi Nakamura,
  • Natsuko Hama,
  • Yasushi Totoki,
  • Akihiko Yoshida,
  • Momoko Nagai,
  • Mamoru Kato,
  • Erika Arakawa,
  • Wakako Mukai,
  • Hirofumi Rokutan,
  • Akira Kawai,
  • Sakae Tanaka,
  • Tatsuhiro Shibata

DOI
https://doi.org/10.1038/s41467-018-03891-9
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 11

Abstract

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Myxofibrosarcoma occurs in adults and is associated with high local relapse. Here, based on exome/transcriptome sequencing and DNA methylation analysis, the authors identify driver genes and methylation clusters associated with unique combinations of mutations, outcomes, and immune cell compositions.