Progress on the pathological roles of immune checkpoint CD276 protein in tumorigenesis and development

Abstract

The immune checkpoint CD276 protein, belonging to the B7 family molecules, could interact with important signaling pathways, such as phosphatidylinositol 3 kinase/protein kinase B(PI3K/AKT)signaling pathway, resulting to the regulation of tumor energy metabolism, inhibition of the anti-tumor activity of immune cells, promotion of tumor angiogenesis, and the assistance of tumor immune escape and metastasis. CD276 also potentially related to tumor stemness and chemotherapy resistance closely. Several antibody drugs and cell therapy methods targeting at CD276 have been proved in clinical trials. CD276 can also be used as a biomarker for tumor diagnosis and subtyping. The upstream regulatory mechanisms of CD276 include transcriptional level regulation mediated by non-coding RNA and transcription factors, and post-translational modification level regulation mediated by methylation and glycosylation.

Keywords

• cd276|tumor immune escape|tumor pathological mechanism|tumor immunotherapy|immune checkpoint