E-cardiac patch to sense and repair infarcted myocardium

Renjie Qiu; Xingying Zhang; Chen Song; Kaige Xu; Huijia Nong; Yi Li; Xianglong Xing; Kibret Mequanint; Qian Liu; Quan Yuan; Xiaomin Sun; Malcolm Xing; Leyu Wang

doi:10.1038/s41467-024-48468-x

Nature Communications (May 2024)

E-cardiac patch to sense and repair infarcted myocardium

Renjie Qiu,
Xingying Zhang,
Chen Song,
Kaige Xu,
Huijia Nong,
Yi Li,
Xianglong Xing,
Kibret Mequanint,
Qian Liu,
Quan Yuan,
Xiaomin Sun,
Malcolm Xing,
Leyu Wang

Affiliations

Renjie Qiu: Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering; Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University
Xingying Zhang: Department of Mechanical Engineering, University of Manitoba
Chen Song: The Fifth Affiliated Hospital of Southern Medical University, Southern Medical University
Kaige Xu: Department of Mechanical Engineering, University of Manitoba
Huijia Nong: Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering; Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University
Yi Li: Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences; Guangdong Provincial Key Laboratory of Single Cell Technology and Application, Southern Medical University
Xianglong Xing: Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering; Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University
Kibret Mequanint: Department of Chemical and Biochemical Engineering, and School of Biomedical Engineering, The University of Western Ontario
Qian Liu: Department of Applied Computer Science, University of Winnipeg
Quan Yuan: State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University
Xiaomin Sun: School of Traditional Chinese Medicine, Southern Medical University
Malcolm Xing: Department of Mechanical Engineering, University of Manitoba
Leyu Wang: Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering; Biomaterials Research Center, School of Biomedical Engineering, Southern Medical University

DOI: https://doi.org/10.1038/s41467-024-48468-x
Journal volume & issue: Vol. 15, no. 1
pp. 1 – 20

Abstract

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Abstract Conductive cardiac patches can rebuild the electroactive microenvironment for the infarcted myocardium but their repair effects benefit by carried seed cells or drugs. The key to success is the effective integration of electrical stimulation with the microenvironment created by conductive cardiac patches. Besides, due to the concerns in a high re-admission ratio of heart patients, a remote medicine device will underpin the successful repair. Herein, we report a miniature self-powered biomimetic trinity triboelectric nanogenerator with a unique double-spacer structure that unifies energy harvesting, therapeutics, and diagnosis in one cardiac patch. Trinity triboelectric nanogenerator conductive cardiac patches improve the electroactivity of the infarcted heart and can also wirelessly monitor electrocardiosignal to a mobile device for diagnosis. RNA sequencing analysis from rat hearts reveals that this trinity cardiac patches mainly regulates cardiac muscle contraction-, energy metabolism-, and vascular regulation-related mRNA expressions in vivo. The research is spawning a device that truly integrates an electrical stimulation of a functional heart patch and self-powered e-care remote diagnostic sensor.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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