Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks

Clemens Neudorfer; Konstantin Butenko; Simon Oxenford; Nanditha Rajamani; Johannes Achtzehn; Lukas Goede; Barbara Hollunder; Ana Sofía Ríos; Lauren Hart; Jordy Tasserie; Kavisha B. Fernando; T. A. Khoa Nguyen; Bassam Al-Fatly; Matteo Vissani; Michael Fox; R. Mark Richardson; Ursula van Rienen; Andrea A. Kühn; Andreas D. Husch; Enrico Opri; Till Dembek; Ningfei Li; Andreas Horn

NeuroImage (Mar 2023)

Lead-DBS v3.0: Mapping deep brain stimulation effects to local anatomy and global networks

Clemens Neudorfer,
Konstantin Butenko,
Simon Oxenford,
Nanditha Rajamani,
Johannes Achtzehn,
Lukas Goede,
Barbara Hollunder,
Ana Sofía Ríos,
Lauren Hart,
Jordy Tasserie,
Kavisha B. Fernando,
T. A. Khoa Nguyen,
Bassam Al-Fatly,
Matteo Vissani,
Michael Fox,
R. Mark Richardson,
Ursula van Rienen,
Andrea A. Kühn,
Andreas D. Husch,
Enrico Opri,
Till Dembek,
Ningfei Li,
Andreas Horn

Affiliations

Clemens Neudorfer: Brain Modulation Lab, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA; Harvard Medical School, Boston, MA, 02114, USA; Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Corresponding authors.
Konstantin Butenko: Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
Simon Oxenford: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Nanditha Rajamani: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Johannes Achtzehn: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Lukas Goede: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Berlin Institute of Health at Charité – Universitätsmedizin Berlin, BIH Biomedical Innovation Academy, BIH Charité Junior Clinician Scientist Program, Berlin, Germany
Barbara Hollunder: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Einstein Center for Neurosciences Berlin, Charité – Universitätsmedizin Berlin, Berlin, Germany; Berlin School of Mind and Brain, Humboldt-Universität zu Berlin, Berlin, Germany
Ana Sofía Ríos: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Lauren Hart: Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
Jordy Tasserie: Division of Neurosurgery, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, ON M5T 2S8, Canada
Kavisha B. Fernando: Melbourne Neuropsychiatry Centre, Department of Psychiatry, The University of Melbourne & Melbourne Health, Melbourne, Australia
T. A. Khoa Nguyen: Department of Neurosurgery, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland
Bassam Al-Fatly: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Matteo Vissani: Brain Modulation Lab, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA; Harvard Medical School, Boston, MA, 02114, USA
Michael Fox: Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA
R. Mark Richardson: Brain Modulation Lab, Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA; Harvard Medical School, Boston, MA, 02114, USA; Department of Neurosurgery, Massachusetts General Hospital, Harvard Medical School, Boston, United States
Ursula van Rienen: Institute of General Electrical Engineering, University of Rostock, Rostock, Germany; Department Life, Light & Matter, University of Rostock, Rostock, Germany; Department Ageing of Individuals and Society, University of Rostock, Rostock, Germany
Andrea A. Kühn: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany
Andreas D. Husch: University of Luxembourg, Luxembourg Centre for Systems Biomedicine, 4362, Esch-sur-Alzette, Luxembourg
Enrico Opri: Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA
Till Dembek: Department of Neurology, Faculty of Medicine and University Hospital Cologne, University of Cologne, Cologne, Germany
Ningfei Li: Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Corresponding authors.
Andreas Horn: Harvard Medical School, Boston, MA, 02114, USA; Center for Brain Circuit Therapeutics Department of Neurology Brigham & Women's Hospital, Harvard Medical School, Boston, MA, USA; Movement Disorder and Neuromodulation Unit, Department of Neurology, Charité -Universitätsmedizin Berlin, corporate member of Freie Universität Berlin and Humboldt-Universität zu Berlin, Berlin, Germany; Corresponding authors.

Journal volume & issue: Vol. 268
p. 119862

Abstract

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Following its introduction in 2014 and with support of a broad international community, the open-source toolbox Lead-DBS has evolved into a comprehensive neuroimaging platform dedicated to localizing, reconstructing, and visualizing electrodes implanted in the human brain, in the context of deep brain stimulation (DBS) and epilepsy monitoring. Expanding clinical indications for DBS, increasing availability of related research tools, and a growing community of clinician-scientist researchers, however, have led to an ongoing need to maintain, update, and standardize the codebase of Lead-DBS. Major development efforts of the platform in recent years have now yielded an end-to-end solution for DBS-based neuroimaging analysis allowing comprehensive image preprocessing, lead localization, stimulation volume modeling, and statistical analysis within a single tool. The aim of the present manuscript is to introduce fundamental additions to the Lead-DBS pipeline including a deformation warpfield editor and novel algorithms for electrode localization. Furthermore, we introduce a total of three comprehensive tools to map DBS effects to local, tract- and brain network-levels. These updates are demonstrated using a single patient example (for subject-level analysis), as well as a retrospective cohort of 51 Parkinson's disease patients who underwent DBS of the subthalamic nucleus (for group-level analysis). Their applicability is further demonstrated by comparing the various methodological choices and the amount of explained variance in clinical outcomes across analysis streams. Finally, based on an increasing need to standardize folder and file naming specifications across research groups in neuroscience, we introduce the brain imaging data structure (BIDS) derivative standard for Lead-DBS. Thus, this multi-institutional collaborative effort represents an important stage in the evolution of a comprehensive, open-source pipeline for DBS imaging and connectomics.

Published in NeuroImage

ISSN: 1053-8119 (Print); 1095-9572 (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neuroimage

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