Early redox activities modulate Xenopus tail regeneration

Fernando Ferreira; VijayKrishna Raghunathan; Guillaume Luxardi; Kan Zhu; Min Zhao

doi:10.1038/s41467-018-06614-2

Nature Communications (Oct 2018)

Early redox activities modulate Xenopus tail regeneration

Fernando Ferreira,
VijayKrishna Raghunathan,
Guillaume Luxardi,
Kan Zhu,
Min Zhao

Affiliations

Fernando Ferreira: Department of Dermatology, Institute for Regenerative Cures, University of California
VijayKrishna Raghunathan: Department of Basic Sciences, College of Optometry, University of Houston
Guillaume Luxardi: Department of Dermatology, Institute for Regenerative Cures, University of California
Kan Zhu: Department of Dermatology, Institute for Regenerative Cures, University of California
Min Zhao: Department of Dermatology, Institute for Regenerative Cures, University of California

DOI: https://doi.org/10.1038/s41467-018-06614-2
Journal volume & issue: Vol. 9, no. 1
pp. 1 – 15

Abstract

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Reactive oxygen species (ROS) and hypoxia-inducible factors (HIF) mediate regeneration but how is unclear. Here, the authors use an optic-based probe (‘optrode’) to monitor oxygen (O2) during Xenopus tail regeneration, identifying crosstalk between O2 influx, ROS production, and HIF-1α stabilization.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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