The regulation of platelet production and therapeutic drugs

Abstract

Platelets are essential blood cells for maintaining hemostasis. Thrombocytopenia and thrombocy‐themia are common platelet-related blood diseases with serious symptom, such as bleeding and thrombosis.Thrombocytopenic arrest and the abnormal clearance of platelets are the main causes of these diseases. The drugsfor the treatment of thrombocytopenia or thrombocythemia are targeting intracellular signaling pathways mediatedby thrombopoietin and its receptors. Moreover, the drugs targeting the platelet clearance have also achieved clini‐cal effects. In this paper, the research progress in the mechanism and clinical effects of various drugs for the treat‐ment of thrombocytopenia and thrombocythemia were reviewed.

Keywords

• thrombocytopoiesis
• thrombocytopenia
• thrombocytosis
• drugs