Nature Communications (Mar 2021)
mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation
- Yilei Zhang,
- Robert V. Swanda,
- Litong Nie,
- Xiaoguang Liu,
- Chao Wang,
- Hyemin Lee,
- Guang Lei,
- Chao Mao,
- Pranavi Koppula,
- Weijie Cheng,
- Jie Zhang,
- Zhenna Xiao,
- Li Zhuang,
- Bingliang Fang,
- Junjie Chen,
- Shu-Bing Qian,
- Boyi Gan
Affiliations
- Yilei Zhang
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Robert V. Swanda
- Graduate Field of Biomedical and Biological Sciences, Cornell University
- Litong Nie
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Xiaoguang Liu
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Chao Wang
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Hyemin Lee
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Guang Lei
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Chao Mao
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Pranavi Koppula
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Weijie Cheng
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Jie Zhang
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Zhenna Xiao
- Department of Genetics, the University of Texas MD Anderson Cancer Center
- Li Zhuang
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Bingliang Fang
- Department of Thoracic and Cardiovascular Surgery, the University of Texas MD Anderson Cancer Center
- Junjie Chen
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- Shu-Bing Qian
- Graduate Field of Biomedical and Biological Sciences, Cornell University
- Boyi Gan
- Department of Experimental Radiation Oncology, the University of Texas MD Anderson Cancer Center
- DOI
- https://doi.org/10.1038/s41467-021-21841-w
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
Glutathione peroxidase 4 (GPX4) inhibits ferroptosis, but protein synthesis is inefficient and costly. Here, the authors reveal that cystine uptake promotes GPX4 synthesis by activating mTORC1 and show that cancer cells are sensitized to ferroptosis by mTORC1 inhibition.
