Nature Communications (Oct 2018)
Helminth-induced IL-4 expands bystander memory CD8 + T cells for early control of viral infection
- Marion Rolot,
- Annette M. Dougall,
- Alisha Chetty,
- Justine Javaux,
- Ting Chen,
- Xue Xiao,
- Bénédicte Machiels,
- Murray E. Selkirk,
- Rick M. Maizels,
- Cornelis Hokke,
- Olivier Denis,
- Frank Brombacher,
- Alain Vanderplasschen,
- Laurent Gillet,
- William G. C. Horsnell,
- Benjamin G. Dewals
Affiliations
- Marion Rolot
- Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine – FARAH, University of Liège
- Annette M. Dougall
- Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine – FARAH, University of Liège
- Alisha Chetty
- Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University of Cape Town
- Justine Javaux
- Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine – FARAH, University of Liège
- Ting Chen
- Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine – FARAH, University of Liège
- Xue Xiao
- Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine – FARAH, University of Liège
- Bénédicte Machiels
- Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine – FARAH, University of Liège
- Murray E. Selkirk
- Department of Life Sciences, Imperial College London
- Rick M. Maizels
- Wellcome Centre for Molecular Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow
- Cornelis Hokke
- Department of Parasitology, Leiden University Medical Center
- Olivier Denis
- Scientific Institute of Public Health, Immunology, Communicable and Infectious Diseases
- Frank Brombacher
- Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University of Cape Town
- Alain Vanderplasschen
- Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine – FARAH, University of Liège
- Laurent Gillet
- Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine – FARAH, University of Liège
- William G. C. Horsnell
- Institute of Infectious Disease and Molecular Medicine and Division of Immunology, University of Cape Town
- Benjamin G. Dewals
- Immunology-Vaccinology, Department of Infectious and Parasitic Diseases, Faculty of Veterinary Medicine – FARAH, University of Liège
- DOI
- https://doi.org/10.1038/s41467-018-06978-5
- Journal volume & issue
-
Vol. 9,
no. 1
pp. 1 – 16
Abstract
Parasitic helminth infection is known to impact upon the host response to other bystander inflammatory processes. Here the authors show that IL4 production induced by helminth infection results in expansion of bystander CD8+ memory T cells and enhanced control to viral infection.
