The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

Bergithe E. Oftedal; Stefano Maio; Adam E. Handel; Madeleine P. J. White; Duncan Howie; Simon Davis; Nicolas Prevot; Ioanna A. Rota; Mary E. Deadman; Benedikt M. Kessler; Roman Fischer; Nikolaus S. Trede; Erdinc Sezgin; Rick M. Maizels; Georg A. Holländer

doi:10.1038/s42003-021-02203-0

Communications Biology (Jun 2021)

The chaperonin CCT8 controls proteostasis essential for T cell maturation, selection, and function

Bergithe E. Oftedal,
Stefano Maio,
Adam E. Handel,
Madeleine P. J. White,
Duncan Howie,
Simon Davis,
Nicolas Prevot,
Ioanna A. Rota,
Mary E. Deadman,
Benedikt M. Kessler,
Roman Fischer,
Nikolaus S. Trede,
Erdinc Sezgin,
Rick M. Maizels,
Georg A. Holländer

Affiliations

Bergithe E. Oftedal: Developmental Immunology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Stefano Maio: Developmental Immunology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Adam E. Handel: Developmental Immunology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Madeleine P. J. White: Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow
Duncan Howie: Sir William Dunn School of Pathology, University of Oxford
Simon Davis: Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
Nicolas Prevot: Developmental Immunology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Ioanna A. Rota: Developmental Immunology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Mary E. Deadman: Developmental Immunology, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Benedikt M. Kessler: Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
Roman Fischer: Target Discovery Institute, Nuffield Department of Medicine, University of Oxford
Nikolaus S. Trede: Huntsman Cancer Institute, University of Utah
Erdinc Sezgin: MRC Human Immunology Unit, MRC Weatherall Institute of Molecular Medicine, University of Oxford
Rick M. Maizels: Wellcome Centre for Integrative Parasitology, Institute of Infection, Immunity and Inflammation, University of Glasgow
Georg A. Holländer: Developmental Immunology, MRC Weatherall Institute of Molecular Medicine, University of Oxford

DOI: https://doi.org/10.1038/s42003-021-02203-0
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 14

Abstract

Read online

Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a failed antigenic response to intestinal helminths.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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