Stabilization of remission in patients with opioid depen dence: pharmacological and pharmacogenetic aspects
Abstract
Modern narcology demonstrates a problem of insufficient effectiveness of pharmacotherapy for stabilization of remission in patients with opioid dependence. Effectiveness of the existing pharmacological approaches to solving this problem varies from patient to patient. In Russia, naltrexone is a medication mainly used for stabilization of remission in patients with opioid dependence. The main course of inefficient effectiveness of naltrexone in treatment of opioid dependence could be explained by poor compliance. The effectiveness can be improved by three ways: 1) using extendedrelease formulations of naltrexone; 2) using naltrexone combined with other medications to reduce symptoms resulting in relapse; 3) conducting a pharmacogenetic analysis to provide patients’ stratification by the effectiveness of pharmacotherapy. The main objective of this review is to analyze opportunities for improving pharmacological treatment methods in stabilization of remission in patients with opioid dependence using the combined pharmacotherapy and pharmacogenetic analysis in order to develop individualized pharmacological treatment approach.
Keywords
