Beilstein Journal of Organic Chemistry (Jul 2016)

Catalytic Chan–Lam coupling using a ‘tube-in-tube’ reactor to deliver molecular oxygen as an oxidant

  • Carl J. Mallia,
  • Paul M. Burton,
  • Alexander M. R. Smith,
  • Gary C. Walter,
  • Ian R. Baxendale

DOI
https://doi.org/10.3762/bjoc.12.156
Journal volume & issue
Vol. 12, no. 1
pp. 1598 – 1607

Abstract

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A flow system to perform Chan–Lam coupling reactions of various amines and arylboronic acids has been realised employing molecular oxygen as an oxidant for the re-oxidation of the copper catalyst enabling a catalytic process. A tube-in-tube gas reactor has been used to simplify the delivery of the oxygen accelerating the optimisation phase and allowing easy access to elevated pressures. A small exemplification library of heteroaromatic products has been prepared and the process has been shown to be robust over extended reaction times.

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